アブストラクト(55巻1号:神奈川歯学)

神奈川歯学

Japanese

Title : ラット顎下腺主導管に分布する神経終末と顎下神経節ニューロンの生後発達に関する形態学的および免疫組織化学的研究
Subtitle : 原著
Authors : 杉村太丈1), 河田亮2), 小口岳史3), 尾之上さくら4), 大西宏祐2), 平野航2), 前田信吾2), 東一善2), 高橋理2)
Authors(kana) :
Organization : 1)神奈川歯科大学大学院歯学研究科口腔統合医療学講座歯科矯正学分野, 2)神奈川歯科大学大学院歯学研究科口腔科学講座神経組織発生学分野, 3)神奈川歯科大学総合教育部, 4)関東学院大学理工学部
Journal : 神奈川歯学
Volume : 55
Number : 1
Page : 29-42
Year/Month : 2020 / 6
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「緒言」ラットでは顎下腺は漿粘液の唾液を分泌している. その分泌機構は交感神経では脊髄側角から起始する線維が上頸神経節でニューロンを換え, 節後線維が, また副交感神経は上唾液核由来の線維が顎下神経節でニューロンを換えて, 顎下腺の分泌や主導管の唾液最終成分調節に関与していると報告されている. 顎下神経節はヒトでは顎下三角に存在し, ラットでは顎下腺主導管に沿って顎下腺門付近から咬筋付近に存在している神経節である. この顎下神経節における研究は顎下神経節が中枢と末梢を連絡する単なるニューロンの中継点として考えられてきたことから, その詳細な研究は行われてこなかった. しかし, 顎下神経節の電子顕微鏡的な構造が報告されている. 彼らの報告によれば, 顎下神経節は結合組織性の被膜に包まれ, 内部に神経細胞体, 神経膠細胞(外套細胞)や神経線維から構成されている.
Practice : 歯科学
Keywords : 顎下腺主導管, 顎下神経節, シナプス, VIP

English

Title : Morphological and immunohistochemical study of postnatal development in rat submandibular ganglion neurons and nerve ending at main excretory ducts of the submandibular gland
Subtitle :
Authors : Takahiro SUGIMURA1), Akira KAWATA2), Takeshi OGUCHI3), Sakura ONOUE4), Kosuke ONISHI2), Wataru HIRANO2), Shingo MAEDA2), Kazuyoshi HIGASHI2), Osamu TAKAHASHI2)
Authors(kana) :
Organization : 1)Division of Orthodontics, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, 2)Division of Histology, Embryology and Neuroanatomy, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 3)Division of Curriculum Development, Kanagawa Dental University, 4)College of Science and Engineering, Kanto Gakuin University
Journal : Kanagawa Shigaku
Volume : 55
Number : 1
Page : 29-42
Year/Month : 2020 / 6
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] We morphologically and immunohistochemically examined at the submandibular ganglion, the number and properties of synapses, which were visualized with an anti-synaptophysin antibody, at the submandibular duct, and the surrounding arterioles during rat postnatal development. The study showed that the number of synaptophysin-immunoreactive puncta in the main excretory duct and arteriole increased with development of the submandibular ganglion. However, the number of synaptophysin-immunoreactive puncta in the main excretory duct increased until 4 weeks of age, but the number of synaptophysin-immunoreactive puncta decreased significantly and rapidly at 8 weeks. This was likely due to the occurrence of pruning that has been reported in the central nervous system. There are no reports to date on this pruning in the submandibular gland. Vasoactive intestinal peptide (VIP)-positive nerve endings were observed from 3 weeks of age. This finding was correlated with the rapid increase in the cross-sectional area of the submandibular ganglion neurons in a time-dependent manner. Although the epithelium of the main excretory duct was stratified until 3 weeks of age, it transitioned to a pseudostratified type from 4 weeks. This change was correlated with the increase in the cross-sectional area of the submandibular ganglion and the decrease in the number of synaptophysin-immunoreactive puncta in a time-dependent manner. It has been reported that VIP is a key regulator of the components in the main excretory duct, indicating that postnatal development of the main excretory duct is closely associated with the submandibular ganglion, number of synapses, and VIP-positive nerve endings.
Practice : Dentistry
Keywords : VIP