アブストラクト（58巻1号：神奈川歯学）

神奈川歯学

English

Title　： Involvement of IL-17 and dental disease in palmoplantar pustulosis
Subtitle　： REVIEWS
Authors　： Tomoko SHIMIZU1), Yoshinori JINBU2), Keiichi TSUKINOKI2)
Authors（kana）　：
Organization　： 1)Department of Implantology and Periodontology, Graduate School of Dentistry, Kanagawa Dental University, 2)Department of Environmental Pathology, Graduate School of Dentistry, Kanagawa Dental University
Journal　： Kanagawa Shigaku
Volume　： 58
Number　： 1
Page　： 48-52
Year/Month　： 2023 / 6
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [Abstract] Palmoplantar pustulosis (PPP) is an intractable skin disease of unknown cause, characterized by the formation of sterile pustules on the palms and soles. PPP has been reported to be associated with the dental diseases, as treatment of dental infected lesions improves skin symptoms. Furthermore, many immunomodulatory functions of the IL-17 family of cytokines produced by Th17 cells have been reported, which are mediated by the induction of many immune signaling molecules. The most notable role of IL-17 is the induction and mediation of proinflammatory responses. Several clinical human studies have reported that excessive IL-17 production is associated with periodontitis, psoriasis, PPP, and rheumatoid arthritis. In apical periodontitis and periodontitis, IL-17 production was observed at the site of inflammation, possibly affecting the increased blood levels. This increase in IL-17 may be involved in the development of PPP; however, the mechanism linking PPP and dental disease is unknown.
Practice　： Dentistry
Keywords　： PPP, IL-17, Apical Periodontitis, Periodontitis